ncRNA name | hsa-miR-2113 |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human Müller cell line MIO-M1 |
Methods | qPCR, Western blot, immunouorescent staining |
Expression pattern | down-regulated |
Functional description | HG-increased MMP-2 and MMP-9 and HG-decreased TIMP-2 in Müller cells. HG up-regulates Zeb1 and lncRNA RP11-982M15.8, and down-regulates miR-2113, and Rg1 inhibits these effects of HG. Both inhibition of miR-2113 and over-expression of RP11-982M15.8 significantly restored the HG induced mesenchymal activasion. |
PubMed ID | 29654764 |
Year | 2018 |
Title | Rg1 inhibits high glucose-induced mesenchymal activation and fibrosis via regulating miR-2113/RP11-982M15.8/Zeb1 pathway. |
Drug-related ncRNA | YES (Ginsenoside Rg1) |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.